Unlocking Secrets in Nerve Repair: From Neuronal Signaling to Glial Modulation
Abstract
: Valeria Cavalli and her team study the mechanisms by which sensory neurons, with cell bodies in dorsal root ganglia, respond to injury and regenerate their axons. They have identified multiple neuronal pathways that enhance axon growth capacity. Additionally, their research has demonstrated that satellite glial cells (SGCs), which envelop the sensory neuron soma, play a role in nerve repair. The pathways identified in rodent SGCs have been shown to be conserved in human SGCs. Cavalli's team is extending these studies to explore the contribution of SGCs to sensory neuron function and dysfunction in disease states, including autism spectrum disorders, chemotherapy-induced neuropathy, and aging.
Bio:
 Valeria Cavalli is the Robert E. and Louise F. Dunn Professor of Biomedical Research and Professor of Neuroscience at Washington University in St Louis. Her laboratory aims to unravel the molecular and cellular events responsible for repairing damaged axons and identify therapeutic targets to improve neuronal function in the injured nervous system. Dr. Cavalli earned her PhD from the University of Geneva, Switzerland, where she studied the signaling mechanisms regulating membrane trafficking in cells. She continued with postdoctoral training at the University of California, San Diego, where she studied how information about injury is conveyed from the lesion site in the axon back to the soma. She received a post-doctoral fellowship from the Christopher and Dana Reeve Foundation to continue her studies on injury signaling, which was influential in how she pursued her career. She was seized by the puzzle of nerve injury and repair and has been tackling this question since joining Washington University
This annual lecture honours
 Dr. Albert Aguayo
, OC, FRCP, Professor Emeritus founder and former Director of the Centre for the Research in Neuroscience at McGill University. A cocktail reception will follow the lecture.
Unable to attend in person? Join us virtually 
here.
For more information, visit The Neuro's website 
here.
Information Source: The Neuro | eventbrite

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