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Flights from Charleston to Santo Domingo Starting at NZD 328

Whether you’re going for a one-way or round-trip to Santo Domingo, we’ve got you covered! Check out these different flight options from Charleston below.

  • One way
  • Round-trip
      • CHS15:57
        18h 47m
        1 stop
        SDQ11:44
        Thu, Mar 6|Charleston - Santo Domingo|Frontier Airlines
        NZD 328NZD 452
        28% OFF
        28% OFF
        NZD 452NZD 328

        Choose Frontier Airlines flights from Charleston to Santo Domingo. The one-way connecting flight with Frontier Airlines departs from Charleston International Airport on Thu, Mar 6, arriving at Las Américas International Airport. One-way Prices start from NZD 328 including taxes and charges.

      • CHS05:35
        7h 36m
        1 stop
        SDQ13:11
        Wed, Mar 12|Charleston - Santo Domingo|Delta Air Lines
        NZD 345NZD 452
        24% OFF
        24% OFF
        NZD 452NZD 345

        Choose Delta Air Lines flights from Charleston to Santo Domingo. The one-way connecting flight with Delta Air Lines departs from Charleston International Airport on Wed, Mar 12, arriving at Las Américas International Airport. One-way Prices start from NZD 345 including taxes and charges.

      • CHS17:13
        8h 8m
        1 stop
        SDQ01:21
        Fri, Mar 21|Charleston - Santo Domingo|Jetblue Airways
        NZD 358NZD 452
        21% OFF
        21% OFF
        NZD 452NZD 358

        Choose Jetblue Airways flights from Charleston to Santo Domingo. The one-way connecting flight with Jetblue Airways departs from Charleston International Airport on Fri, Mar 21, arriving at Las Américas International Airport. One-way Prices start from NZD 358 including taxes and charges.

      • CHS09:34
        9h 14m
        1 stop
        SDQ19:48
        Wed, Mar 5|Charleston - Santo Domingo|Jetblue Airways
        NZD 368
        NZD 368

        Choose Jetblue Airways flights from Charleston to Santo Domingo. The one-way connecting flight with Jetblue Airways departs from Charleston International Airport on Wed, Mar 5, arriving at Las Américas International Airport. One-way Prices start from NZD 368 including taxes and charges.

      • CHS17:14
        7h 35m
        1 stop
        SDQ01:49
        Thu, Mar 6|Charleston - Santo Domingo|Jetblue Airways
        NZD 372
        NZD 372

        Choose Jetblue Airways flights from Charleston to Santo Domingo. The one-way connecting flight with Jetblue Airways departs from Charleston International Airport on Thu, Mar 6, arriving at Las Américas International Airport. One-way Prices start from NZD 372 including taxes and charges.

      • CHS10:57
        11h 44m
        1 stop
        SDQ22:41
        Fri, Apr 4|Charleston - Santo Domingo|American Airlines
        NZD 384
        NZD 384

        Choose American Airlines flights from Charleston to Santo Domingo. The one-way connecting flight with American Airlines departs from Charleston International Airport on Fri, Apr 4, arriving at Las Américas International Airport. One-way Prices start from NZD 384 including taxes and charges.

      • CHS11:16
        9h 6m
        1 stop
        SDQ20:22
        Sat, Apr 5|Charleston - Santo Domingo|American Airlines
        NZD 386
        NZD 386

        Choose American Airlines flights from Charleston to Santo Domingo. The one-way connecting flight with American Airlines departs from Charleston International Airport on Sat, Apr 5, arriving at Las Américas International Airport. One-way Prices start from NZD 386 including taxes and charges.

      • CHS17:14
        19h 55m
        1 stop
        SDQ13:09
        Sat, Mar 8|Charleston - Santo Domingo|Jetblue Airways
        NZD 388
        NZD 388

        Choose Jetblue Airways flights from Charleston to Santo Domingo. The one-way connecting flight with Jetblue Airways departs from Charleston International Airport on Sat, Mar 8, arriving at Las Américas International Airport. One-way Prices start from NZD 388 including taxes and charges.

      • CHS09:34
        9h 10m
        1 stop
        SDQ18:44
        Fri, Mar 14|Charleston - Santo Domingo|Jetblue Airways
        NZD 403
        NZD 403

        Choose Jetblue Airways flights from Charleston to Santo Domingo. The one-way connecting flight with Jetblue Airways departs from Charleston International Airport on Fri, Mar 14, arriving at Las Américas International Airport. One-way Prices start from NZD 403 including taxes and charges.

      • CHS17:14
        9h 38m
        1 stop
        SDQ02:52
        Mon, Mar 17|Charleston - Santo Domingo|Jetblue Airways
        NZD 405
        NZD 405

        Choose Jetblue Airways flights from Charleston to Santo Domingo. The one-way connecting flight with Jetblue Airways departs from Charleston International Airport on Mon, Mar 17, arriving at Las Américas International Airport. One-way Prices start from NZD 405 including taxes and charges.

      • CHS01:00 pm
        3h 5m
        Nonstop
        SDQ02:00 pm
        Thu, Feb 27|Charleston - Santo Domingo|Frontier Airlines
        Find More Flights
        Find More Flights

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Charleston to Santo Domingo flight time & flight schedules

Flight info.
Departure
Arrival
Weekly Schedule

  1. DL3055

    Delta Air Lines

    05:30

    CHS

    1.2h

    06:40

    ATL

    SMTWTFS
    Search

  2. DL323

    Delta Air Lines

    07:30

    ATL

    2.3h

    09:45

    LGA

    SMTWT-S

  3. DL1908

    Delta Air Lines

    14:30

    JFK

    4.0h

    18:27

    SDQ

    SMTWTFS

  4. DL3055

    Delta Air Lines

    05:30

    CHS

    1.2h

    06:40

    ATL

    SMTWTFS
    Search

  5. DL1958

    Delta Air Lines

    09:46

    ATL

    3.3h

    13:05

    SDQ

    SMTWTFS

  6. UA1289

    United Airlines

    06:00

    CHS

    2.0h

    07:59

    EWR

    SMTWTFS
    Search

  7. UA2404

    United Airlines

    10:12

    EWR

    4.0h

    14:10

    SDQ

    SMTWTFS

  8. DL2124

    Delta Air Lines

    06:30

    CHS

    1.3h

    07:45

    ATL

    SMTWTFS
    Search

  9. DL1034

    Delta Air Lines

    09:00

    ATL

    2.3h

    11:18

    JFK

    SMTWTFS

  10. DL1908

    Delta Air Lines

    14:30

    JFK

    4.0h

    18:27

    SDQ

    SMTWTFS

  11. B62874

    Jetblue Airways

    11:07

    CHS

    1.9h

    12:59

    JFK

    SMTWTFS
    Search

  12. B6609

    Jetblue Airways

    14:55

    JFK

    3.8h

    18:44

    SDQ

    -MT----

  13. B6068

    Jetblue Airways

    11:42

    CHS

    2.4h

    14:04

    BOS

    S-TWTFS
    Search

  14. B61629

    Jetblue Airways

    10:07

    BOS

    4.2h

    14:17

    SDQ

    -MT----

  15. DL3107

    Delta Air Lines

    12:15

    CHS

    1.3h

    13:30

    ATL

    SMTWTFS
    Search

  16. DL2466

    Delta Air Lines

    17:40

    ATL

    2.4h

    20:05

    JFK

    SMTWTFS

  17. DL1943

    Delta Air Lines

    19:29

    JFK

    4.1h

    23:35

    SDQ

    SMTWTFS

  18. AA5019

    American Airlines

    12:49

    CHS

    1.1h

    13:55

    CLT

    SMTWTFS
    Search

  19. AA2645

    American Airlines

    14:30

    CLT

    2.2h

    16:42

    MIA

    SMTWTFS

  20. AA368

    American Airlines

    18:32

    MIA

    2.3h

    20:47

    SDQ

    SM-WTFS

  21. B61274

    Jetblue Airways

    18:59

    CHS

    2.1h

    21:04

    JFK

    SMTWTFS
    Search

  22. B6745

    Jetblue Airways

    05:01

    JFK

    3.8h

    08:48

    SDQ

    SMTWTFS

  23. B61274

    Jetblue Airways

    18:59

    CHS

    2.1h

    21:04

    JFK

    SMTWTFS
    Search

  24. B6709

    Jetblue Airways

    21:25

    JFK

    4.0h

    01:27

    SDQ

    SMTWTFS
Find more flights and airlines

Find the best time to fly from Charleston to Santo Domingo

These price trend charts carefully monitor and predict how flight prices from Charleston to Santo Domingo will change. Keep a close eye on them to understand when the best time to buy your tickets is.

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

FAQ

  • When are flight tickets from Charleston (CHS) to Santo Domingo (SDQ) the cheapest?

    Airlines adjust prices for flights from Charleston to Santo Domingo based on the date and time of your booking. By analyzing data from all airlines, on Trip.com, you can find the cheapest flight prices on Tuesdays, Wednesdays, and Saturdays.

  • How much are flights from Charleston (CHS) to Santo Domingo (SDQ) cost?

    According to Trip.com's data, the lowest price is around NZD 784.

  • What is the transportation method from the main airport to downtown in Santo Domingo?

    • The distance from Las Américas International Airport to downtown is about 33km, by taxi about 50 minutes.
    • The distance from La Isabela International Airport to downtown is about 8km, by taxi about 20 minutes.

  • How many airports in Santo Domingo (SDQ)?

    There are 2 airport(s) in Santo Domingo (SDQ): La Isabela International Airport and Las Américas International Airport.

How to find a cheap flight from Charleston to Santo Domingo

If you leave it until the last minute and forget to check some of the key information when booking tickets, prices can often end up skyrocketing. Below, you can find our top tips for getting the best value flights – from changing dates to chasing deals, there are plenty ways to keep your next trip affordable.
1
Be flexible with your travel dates to get the cheapest flight from Charleston to Santo Domingo.
Simply tap "Date" on the flight search bar to browse through the calendar and check out airfare from Charleston to Santo Domingo over the next 6 months in 2025. If you're planning to fly within the next three months, it looks like the most affordable option is on Thu, Mar 6, with one-way flights priced at just NZD 328.
2
Compare cheap flight deals from Charleston to Santo Domingo across hundreds of airlines.
With our extensive search, you can compare prices from over 500 airlines to find the cheapest flight tickets from Charleston to Santo Domingo. The cheapest airline for this route is Frontier Airlines.
3
Set up a Price Alert
By setting up a Price Alert for your journey from Charleston to Santo Domingo, you can easily keep an eye on ticket prices without having to check every day.
4
Don't miss out on cheap flight deals and promo codes from Charleston to Santo Domingo.
You can always find the latest offers through Trip.com Deals and Promo Codes for cheap flights. By signing up for a free membership, you'll get access to even more deals for your flights.
5
Book early or wait until the last minute.
It's usually best to book early. Flight tickets are often cheapest when they're first released, typically about a year before the departure date. So, have a look online as soon as the flights you're interested in become available. If you miss the cheapest time, you might still find some good deals as the departure date gets closer.
6
Search for flights on the go.
For the best travel flight booking experience, download the Trip.com app. You can search for cheap flights from Charleston to Santo Domingo and snag some exclusive deals just for you.

Flight Information from Charleston to Santo Domingo

Cheapest direct flight priceNZD 327
Off-season travel monthMarch
Peak season for travelNovember
Flight distance1,896.86km
Popular airlineJetblue Airways

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