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Flights from Madrid to Santiago

Explore the cheapest one-way and round-trip flights from Madrid to Santiago over the next 90 days, with one-way fares from £453 and round-trip from £638. Based on Trip.com's latest 7-day flight data.

      • Cheapest nonstop
        MAD 11:15
        13h 30m
        Direct
        SCL 20:45
        Madrid - Santiago | Fri, Nov 6 | LATAM Airlines
        SCL 12:50
        12h 35m
        Direct
        MAD 05:25
        Santiago - Madrid | Wed, Nov 11 | Iberia
        £731 £894
        18% off
        18% off
        £894 £731
      • MAD 11:15
        13h 30m
        Direct
        SCL 20:45
        Madrid - Santiago | Thu, Nov 12 | LATAM Airlines
        SCL 00:50
        12h 40m
        Direct
        MAD 17:30
        Santiago - Madrid | Thu, Nov 19 | Iberia
        £733 £894
        18% off
        18% off
        £894 £733
      • MAD 09:50
        27h 25m
        1 stop
        SCL 08:15
        Madrid - Santiago | Fri, Oct 23 | Delta Air Lines
        SCL 20:40
        33h 15m
        1 stop
        MAD 09:55
        Santiago - Madrid | Mon, Oct 26 | Delta Air Lines
        £638 £894
        28% off
        28% off
        £894 £638
      • MAD 09:50
        27h 25m
        1 stop
        SCL 08:15
        Madrid - Santiago | Wed, Oct 14 | Delta Air Lines
        SCL 20:40
        34h 35m
        1 stop
        MAD 12:15
        Santiago - Madrid | Tue, Oct 20 | Delta Air Lines
        £638
        28% off
        £894 £638
      • MAD 13:25
        29h 45m
        2 stops
        SCL 15:10
        Madrid - Santiago | Sat, Nov 7 | Air Canada
        SCL 00:50
        12h 40m
        Direct
        MAD 17:30
        Santiago - Madrid | Mon, Nov 9 | Iberia
        £641
        28% off
        £894 £641
      • MAD 00:40
        25h 10m
        1 stop
        SCL 21:50
        Madrid - Santiago | Sat, Nov 7 | LATAM Airlines
        SCL 12:50
        12h 35m
        Direct
        MAD 05:25
        Santiago - Madrid | Mon, Nov 9 | Iberia
        £662
        26% off
        £894 £662
      • MAD 00:40
        18h 20m
        1 stop
        SCL 15:00
        Madrid - Santiago | Thu, Nov 12 | LATAM Airlines
        SCL 12:50
        12h 35m
        Direct
        MAD 05:25
        Santiago - Madrid | Thu, Nov 19 | Iberia
        £663
        26% off
        £894 £663
      • MAD 10:10
        18h 55m
        1 stop
        SCL 01:05
        Madrid - Santiago | Sun, Nov 15 | avianca
        SCL 12:50
        12h 35m
        Direct
        MAD 05:25
        Santiago - Madrid | Sat, Nov 21 | Iberia
        £668
        25% off
        £894 £668
      • MAD 10:10
        23h 25m
        1 stop
        SCL 05:35
        Madrid - Santiago | Tue, Nov 10 | avianca
        SCL 00:50
        12h 40m
        Direct
        MAD 17:30
        Santiago - Madrid | Sat, Nov 14 | Iberia
        £669
        25% off
        £894 £669
      • MAD 01:20
        32h 10m
        1 stop
        SCL 05:30
        Madrid - Santiago | Wed, Nov 11 | avianca
        SCL 22:00
        13h
        Direct
        MAD 15:00
        Santiago - Madrid | Sat, Nov 14 | LATAM Airlines
        £688
        23% off
        £894 £688
      • MAD 11:05
        23h 40m
        1 stop
        SCL 05:45
        Madrid - Santiago | Fri, Oct 23 | avianca
        SCL 20:00
        12h 55m
        Direct
        MAD 12:55
        Santiago - Madrid | Mon, Oct 26 | LATAM Airlines
        £690
        23% off
        £894 £690
      • MAD 16:20
        36h 45m
        1 stop
        SCL 01:05
        Madrid - Santiago | Tue, Oct 27 | avianca
        SCL 00:50
        12h 40m
        Direct
        MAD 17:30
        Santiago - Madrid | Sun, Nov 1 | Iberia
        £690
        23% off
        £894 £690
      • MAD 13:00
        17h 25m
        1 stop
        SCL 14:00
        Madrid - Santiago | Fri, Sep 18 | Normal Airline
        SCL 15:00
        6h
        Direct
        MAD 16:00
        Santiago - Madrid | Sun, Sep 20 | Normal Airline
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      • Cheapest nonstop
        MAD 23:35
        12h 20m
        Direct
        SCL 07:55
        Madrid - Santiago | Thu, Nov 12 | LATAM Airlines
        £457 £687
        33% off
        33% off
        £687 £457
      • MAD 23:59
        13h 21m
        Direct
        SCL 09:20
        Madrid - Santiago | Thu, Nov 12 | Iberia
        £563 £687
        18% off
        18% off
        £687 £563
      • MAD 06:35
        26h 55m
        1 stop
        SCL 05:30
        Madrid - Santiago | Fri, Nov 6 | avianca
        £453 £687
        34% off
        34% off
        £687 £453
      • MAD 13:50
        38h 30m
        1 stop
        SCL 23:20
        Madrid - Santiago | Wed, Sep 23 | Azul Airlines
        £461
        33% off
        £687 £461
      • MAD 16:20
        27h
        1 stop
        SCL 15:20
        Madrid - Santiago | Sat, Nov 7 | avianca
        £470
        32% off
        £687 £470
      • MAD 13:50
        38h 30m
        1 stop
        SCL 23:20
        Madrid - Santiago | Sun, Sep 27 | Azul Airlines
        £486
        28% off
        £687 £486
      • MAD 13:50
        38h 30m
        1 stop
        SCL 23:20
        Madrid - Santiago | Fri, Sep 25 | Azul Airlines
        £501
        27% off
        £687 £501
      • MAD 13:50
        26h 40m
        1 stop
        SCL 11:30
        Madrid - Santiago | Fri, Sep 18 | Azul Airlines
        £510
        26% off
        £687 £510
      • MAD 13:50
        32h 26m
        1 stop
        SCL 17:16
        Madrid - Santiago | Sun, Oct 18 | Azul Airlines
        £511
        26% off
        £687 £511
      • MAD 13:50
        32h 26m
        1 stop
        SCL 17:16
        Madrid - Santiago | Sun, Oct 4 | Azul Airlines
        £514
        25% off
        £687 £514
      • MAD 01:20
        32h 10m
        1 stop
        SCL 05:30
        Madrid - Santiago | Fri, Oct 30 | avianca
        £517
        25% off
        £687 £517
      • MAD 23:45
        33h 40m
        1 stop
        SCL 05:25
        Madrid - Santiago | Mon, Nov 9 | Air Europa
        £518
        25% off
        £687 £518
      • MAD 13:00
        17h 25m
        1 stop
        SCL 14:00
        Madrid - Santiago | Fri, Sep 18 | Normal Airline
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        Find more flights

Flight.News
Flights from Madrid to Santiago operate an average of 16 times per day over the past 7 days, with a 19.8% on-time departure rate and a 92.9% on-time arrival rate.

Which airlines are the most popular for Madrid to Santiago flights?

The most popular airlines flying from Madrid to Santiago are LATAM Airlines, avianca, and Iberia, among 3 carriers on this route. avianca offers the lowest fares. Based on Trip.com's flight booking data from the previous 12 months.
LATAM Airlines logo LATAM Airlines
avianca logo avianca
Iberia logo Iberia
Airlines are determined based on actual purchased flight tickets from Madrid to Santiago according to previous 12 months data from Trip.com.

Trip.com Price Insights on Madrid to Santiago Flights

What is the cheapest month to book a one-way flight from Madrid to Santiago?

Average price of one-way tickets from Madrid to Santiago booked on Trip.com over the past 12 months.

For a one-way flight from Madrid to Santiago, fares are lowest in May (£382) and highest in July (£735).

£735
£559
£382
£206
    Cheapest
  • £504
    Sep
  • £566
    Oct
  • £536
    Nov
  • £545
    Dec
  • £512
    Jan
  • £555
    Feb
  • £409
    Mar
  • £431
    Apr
  • £382
    May
  • £480
    Jun
  • £735
    Jul
  • £523
    Aug

What is the cheapest month to book a return flight from Madrid to Santiago?

Average price of return tickets from Madrid to Santiago booked on Trip.com over the past 12 months.

For a return flight from Madrid to Santiago, fares are lowest in April (£784) and highest in September (£1,298).

£1,298
£1,041
£784
£527
    Cheapest
  • £1,298
    Sep
  • £1,048
    Oct
  • £881
    Nov
  • £1,131
    Dec
  • £810
    Jan
  • £873
    Feb
  • £803
    Mar
  • £784
    Apr
  • £881
    May
  • £883
    Jun
  • £1,181
    Jul
  • £982
    Aug

Flight FAQs

  • Which airlines offer the cheapest flights from Madrid to Santiago?

    Based on Trip.com data, avianca offers Cheapest nonstop one-way flights from £453 (for example, MAD–SCL on Fri, Nov 6). For a Cheapest nonstop return flight, Delta Air Lines offers fares from £638, departing on Fri, Oct 23 and returning on Mon, Oct 26.
  • At the moment, you can catch a direct flight from Madrid to Santiago with the following airlines, including: LATAM Airlines Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.
  • A flight from Madrid (MAD) to Santiago (SCL) takes an average of 13 hours 48 minutes.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Madrid to Santiago is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • On average, 57 direct flights operate each week between Madrid and Santiago. See below the schedules of the main airlines serving this route:
    LATAM Airlines: S/M/T/W/T/F/S – LA715 (departure at 00:05)
  • Here are some tips for finding the best flight deals from Madrid to Santiago on Trip.com:
    · Be flexible with your travel dates. The cheapest flight is currently on Fri, Nov 6, with one-way fares from just £453.
    · Compare airlines. LATAM Airlines currently offers the lowest fares on this route.
    · Set up a price alert to track fare changes without searching every day.
    · Check Trip.com regularly for flight deals and available promo codes.
    · Avoid peak season or book early. July is generally the busiest month for travel to Santiago.
    · Get exclusive promo codes on the Trip.com app.
  • The cheapest month to book a flight from Madrid to Santiago is usually September, when demand is lower.
  • After crunching the numbers on our September flight calendar, it's currently cheapest to fly from Madrid to Santiago on September 18, 2026 with LATAM Airlines, with prices starting at £637.
  • Flights to Santiago can arrive at: Arturo Merino Benitez International Airport (SCL). The most common route connects Madrid Barajas Airport and Arturo Merino Benitez International Airport (MAD–SCL).
  • The time difference between Santiago and Madrid is 5h.
  • Tickets can only be changed or cancelled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.
  • Based on Trip.com data for flights departing in the next 30 days, the average one-way fare from Madrid to Santiago is £774. Fares vary by travel date, airline and availability.
  • Based on Trip.com data for flights departing in the next 30 days, the average return fare from Madrid to Santiago is £1,062. Fares vary by travel date, airline and availability.
  • Enter Madrid and Santiago, choose your travel dates and passengers, then compare flights by price, duration and baggage. Select a fare, review the change and cancellation rules, enter traveller details and complete payment to receive your confirmation.
  • Sky Airlineare the most popular budget airlines flying from Madrid to Santiago. Check baggage, seat and payment fees before comparing the final price.

More Flight Itineraries

Note: Prices shown on this page are the estimated lowest prices and include all taxes and fees found in the last 24 hours.

Book with no extra fees

Prices displayed on this page are all-inclusive (including taxes, fuel surcharges, civil aviation development fund, etc.), with all fees confirmed before payment. Fees for luggage, meals, Wi-Fi, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page have been updated within the last 24 hours—sometimes even in real time. The more popular the route, the more accurate the data.

Change & Cancellation Policy

Trip.com shows the cancellation and change policies for each flight ticket during the booking process, including any fees and applicable conditions. Please check the following scenarios:
Voluntary cancellation/change:
To request a change or cancellation, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and flight segment, and submit your request. Please note that additional charges may apply according to the airline's ticket policy.
Cancellation/change due to a flight schedule change:
If the flight schedule has changed and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please visit the customer support pages.