Trip.com
>
Cheap Flights
>
United States
>
St. Louis
Hotels in St. Louis
>
Flights from Manchester to St. Louis

Airlines Flying from Manchester to St. Louis

Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

We've found these cheap flights for you. You can book one-way or return flight tickets.

      • MHT 13:00
        17h 25m
        1 stop
        STL Invalid Date
        Manchester - St. Louis | Thu, Nov 20 | Normal Airline
        STL 15:00
        6h
        Direct
        MHT 16:00
        St. Louis - Manchester | Sat, Nov 22 | Normal Airline
        Search
        Search
      • MHT 13:00
        17h 25m
        1 stop
        STL Invalid Date
        Manchester - St. Louis | Thu, Nov 20 | Normal Airline
        STL 15:00
        6h
        Direct
        MHT 16:00
        St. Louis - Manchester | Sat, Nov 22 | Normal Airline
        Search
        Search
      • MHT 13:00
        17h 25m
        1 stop
        STL Invalid Date
        Manchester - St. Louis | Thu, Nov 20 | Normal Airline
        STL 15:00
        6h
        Direct
        MHT 16:00
        St. Louis - Manchester | Sat, Nov 22 | Normal Airline
        Search
        Search
      • MHT 13:00
        17h 25m
        1 stop
        STL Invalid Date
        Manchester - St. Louis | Thu, Nov 20 | Normal Airline
        STL 15:00
        6h
        Direct
        MHT 16:00
        St. Louis - Manchester | Sat, Nov 22 | Normal Airline
        Search
        Search
      • MHT 13:00
        17h 25m
        1 stop
        STL Invalid Date
        Manchester - St. Louis | Thu, Nov 20 | Normal Airline
        STL 15:00
        6h
        Direct
        MHT 16:00
        St. Louis - Manchester | Sat, Nov 22 | Normal Airline
        Search
        Search
      • MHT 13:00
        17h 25m
        1 stop
        STL Invalid Date
        Manchester - St. Louis | Thu, Nov 20 | Normal Airline
        STL 15:00
        6h
        Direct
        MHT 16:00
        St. Louis - Manchester | Sat, Nov 22 | Normal Airline
        Search
        Search
      • MHT 13:00
        17h 25m
        1 stop
        STL Invalid Date
        Manchester - St. Louis | Thu, Nov 20 | Normal Airline
        STL 15:00
        6h
        Direct
        MHT 16:00
        St. Louis - Manchester | Sat, Nov 22 | Normal Airline
        Search
        Search
      • MHT 13:00
        17h 25m
        1 stop
        STL Invalid Date
        Manchester - St. Louis | Thu, Nov 20 | Normal Airline
        STL 15:00
        6h
        Direct
        MHT 16:00
        St. Louis - Manchester | Sat, Nov 22 | Normal Airline
        Search
        Search
      • MHT 13:00
        17h 25m
        1 stop
        STL Invalid Date
        Manchester - St. Louis | Thu, Nov 20 | Normal Airline
        STL 15:00
        6h
        Direct
        MHT 16:00
        St. Louis - Manchester | Sat, Nov 22 | Normal Airline
        Search
        Search

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Flight Information from Manchester to St. Louis

The distance between Manchester and St. Louis is about 1,645.96km. The most popular month to St. Louis is September. The off-season for travel is October.

Cheapest one-way flight price£176
Off-season travel monthOctober
Peak season for travelSeptember
Flight distance1,645.96km

Find the best time to fly from Manchester to St. Louis

The cheapest time for Manchester to St. Louis flights: Jan 18 to Jan 25 — one way flight prices from £113.

Cheapest flights
From price
Search
  • 1623
  • 2330

  • Dec

    307
  • 714
  • 1421
  • 2128

  • Jan

    284
  • 411
  • 1118
  • 1825

  • Feb

    251
  • 18
Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

FAQ

  • When is the best time to book flights from Manchester to St. Louis?

    By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Manchester to St. Louis is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • The cheapest months to fly from Manchester to St. Louis is October, when demand for travel is lower.
  • After crunching the numbers on our November flight calendar, it's currently cheapest to fly from Manchester to St. Louis on November 23, 2025 with American Airlines, with prices starting at £278.
  • The time difference between St. Louis and Manchester is 1h.
  • Tickets can only be changed or cancelled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

More Flight Itineraries