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Flights from Medellin to Sao Paulo

What to know about flights from Medellin to Sao Paulo?

The distance between Medellin and Sao Paulo is approximately 4,564.88km. According to Trip.com data, travel demand is highest in January. September is generally the cheapest month to book.

Cheapest one-way
£214
LATAM Airlines LATAM Airlines MDE-SAO 18h 15m · 1 stop Sat, Nov 28
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Cheapest return
£363
JetSMART Airlines JetSMART Airlines MDE-SAO 16h 34m · 2 stops Sun, Oct 25 - Thu, Oct 29
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Recommended airlines
LATAM Airlines LATAM Airlines Cheapest · From £214 avianca avianca Most booked
Best time to book
December
Cheapest
January
Peak season for travel
Route details
4,564.88km
Flight distance

Explore the cheapest one-way and round-trip flights from Medellin to Sao Paulo over the next 90 days, with one-way fares from £214 and round-trip from £363. Based on Trip.com's latest 7-day flight data.

      • MDE 17:01
        16h 34m
        1 stop
        GRU 11:35
        Medellin - Sao Paulo | Sun, Oct 25 | JetSMART Airlines
        GRU 01:00
        14h 38m
        1 stop
        MDE 13:38
        Sao Paulo - Medellin | Thu, Oct 29 | DM Airlines
        £363 £462
        21% off
        21% off
        £462 £363
      • MDE 18:10
        12h 35m
        1 stop
        GRU 08:45
        Medellin - Sao Paulo | Thu, Oct 29 | LATAM Airlines
        GRU 16:15
        9h 40m
        1 stop
        MDE 23:55
        Sao Paulo - Medellin | Sat, Oct 31 | LATAM Airlines
        £386 £462
        16% off
        16% off
        £462 £386
      • MDE 05:35
        9h
        1 stop
        GRU 16:35
        Medellin - Sao Paulo | Fri, Nov 27 | LATAM Airlines
        GRU 06:30
        11h 55m
        1 stop
        MDE 16:25
        Sao Paulo - Medellin | Sun, Nov 29 | LATAM Airlines
        £389 £462
        16% off
        16% off
        £462 £389
      • MDE 18:20
        27h 55m
        1 stop
        GRU 00:15
        Medellin - Sao Paulo | Sun, Oct 25 | Copa Airlines
        GRU 01:00
        14h 38m
        1 stop
        MDE 13:38
        Sao Paulo - Medellin | Thu, Oct 29 | DM Airlines
        £389
        16% off
        £462 £389
      • MDE 19:55
        10h 25m
        1 stop
        GRU 08:20
        Medellin - Sao Paulo | Wed, Nov 11 | LATAM Airlines
        GRU 16:15
        9h 40m
        1 stop
        MDE 23:55
        Sao Paulo - Medellin | Mon, Nov 16 | LATAM Airlines
        £394
        15% off
        £462 £394
      • MDE 12:40
        9h 30m
        1 stop
        GRU 00:10
        Medellin - Sao Paulo | Thu, Oct 29 | Copa Airlines
        GRU 04:50
        11h 25m
        1 stop
        MDE 14:15
        Sao Paulo - Medellin | Sat, Oct 31 | Copa Airlines
        £398
        14% off
        £462 £398
      • MDE 18:15
        9h 55m
        1 stop
        GRU 06:10
        Medellin - Sao Paulo | Fri, Oct 23 | LATAM Airlines
        GRU 06:30
        11h 55m
        1 stop
        MDE 16:25
        Sao Paulo - Medellin | Tue, Oct 27 | LATAM Airlines
        £401
        13% off
        £462 £401
      • MDE 09:45
        9h 40m
        1 stop
        GRU 21:25
        Medellin - Sao Paulo | Mon, Nov 23 | LATAM Airlines
        GRU 06:30
        11h 55m
        1 stop
        MDE 16:25
        Sao Paulo - Medellin | Sun, Nov 29 | LATAM Airlines
        £407
        12% off
        £462 £407
      • MDE 16:30
        9h 20m
        1 stop
        GRU 03:50
        Medellin - Sao Paulo | Sat, Oct 17 | Copa Airlines
        GRU 05:00
        29h 15m
        1 stop
        MDE 08:15
        Sao Paulo - Medellin | Thu, Oct 22 | Copa Airlines
        £414
        10% off
        £462 £414
      • MDE 18:10
        20h 15m
        1 stop
        GRU 16:25
        Medellin - Sao Paulo | Thu, Nov 26 | LATAM Airlines
        GRU 16:15
        15h 50m
        1 stop
        MDE 06:05
        Sao Paulo - Medellin | Tue, Dec 1 | LATAM Airlines
        £420
        9% off
        £462 £420
      • MDE 13:00
        17h 25m
        1 stop
        SAO 14:00
        Medellin - Sao Paulo | Wed, Oct 14 | Normal Airline
        SAO 15:00
        6h
        Direct
        MDE 16:00
        Sao Paulo - Medellin | Fri, Oct 16 | Normal Airline
        Find more flights
        Find more flights
      • MDE 18:10
        18h 15m
        1 stop
        GRU 14:25
        Medellin - Sao Paulo | Sat, Nov 28 | LATAM Airlines
        £214 £352
        39% off
        39% off
        £352 £214
      • MDE 22:45
        15h 20m
        1 stop
        GRU 16:05
        Medellin - Sao Paulo | Thu, Oct 22 | Gol Linhas Aereas Inteligentes
        £216 £352
        39% off
        39% off
        £352 £216
      • MDE 05:10
        13h 10m
        1 stop
        GRU 20:20
        Medellin - Sao Paulo | Fri, Oct 30 | LATAM Airlines
        £217 £352
        38% off
        38% off
        £352 £217
      • MDE 07:10
        12h 15m
        1 stop
        GRU 21:25
        Medellin - Sao Paulo | Fri, Nov 13 | LATAM Airlines
        £218
        38% off
        £352 £218
      • MDE 08:55
        9h 25m
        1 stop
        GRU 20:20
        Medellin - Sao Paulo | Sat, Oct 24 | LATAM Airlines
        £264
        25% off
        £352 £264
      • MDE 18:10
        20h 15m
        1 stop
        GRU 16:25
        Medellin - Sao Paulo | Fri, Nov 6 | LATAM Airlines
        £279
        21% off
        £352 £279
      • MDE 04:50
        15h 40m
        1 stop
        GRU 22:30
        Medellin - Sao Paulo | Tue, Oct 20 | avianca
        £295
        16% off
        £352 £295
      • MDE 05:10
        13h 10m
        1 stop
        GRU 20:20
        Medellin - Sao Paulo | Tue, Oct 20 | LATAM Airlines
        £302
        14% off
        £352 £302
      • MDE 13:15
        14h 10m
        1 stop
        GRU 05:25
        Medellin - Sao Paulo | Tue, Oct 20 | Gol Linhas Aereas Inteligentes
        £314
        11% off
        £352 £314
      • MDE 07:05
        11h 15m
        1 stop
        GRU 20:20
        Medellin - Sao Paulo | Thu, Oct 22 | LATAM Airlines
        £320
        9% off
        £352 £320
      • MDE 13:00
        17h 25m
        1 stop
        SAO 14:00
        Medellin - Sao Paulo | Wed, Oct 14 | Normal Airline
        Find more flights
        Find more flights

Flight.News
INMET has issued a severe weather warning for Sao Paulo, effective from 11/10/2026 at 00:01. The area faces rainfall between 30 and 60 mm/h (or 50–100 mm/day), intense winds of 60–100 km/h, and hail. Potential hazards include power cuts, damage to crops, falling trees, and flooding.

Which airlines are the most popular for Medellin to Sao Paulo flights?

The most popular airlines flying from Medellin to Sao Paulo are avianca, Gol Linhas Aereas Inteligentes, and Copa Airlines, among 4 carriers on this route. LATAM Airlines offers the lowest fares. Based on Trip.com's flight booking data from the previous 12 months.
avianca logo avianca
Gol Linhas Aereas Inteligentes logo Gol Linhas Aereas Inteligentes
Copa Airlines logo Copa Airlines
LATAM Airlines logo LATAM Airlines
Airlines are determined based on actual purchased flight tickets from Medellin to Sao Paulo according to previous 12 months data from Trip.com.

Trip.com Price Insights on Medellin to Sao Paulo Flights

What is the cheapest month to book a one-way flight from Medellin to Sao Paulo?

Average price of one-way tickets from Medellin to Sao Paulo booked on Trip.com over the past 12 months.

For a one-way flight from Medellin to Sao Paulo, fares are lowest in December (£234) and highest in September (£455).

£455
£345
£234
£124
    Cheapest
  • £293
    Oct
  • £256
    Nov
  • £234
    Dec
  • £290
    Jan
  • £291
    Feb
  • £296
    Mar
  • £270
    Apr
  • £293
    May
  • £284
    Jun
  • £412
    Jul
  • £376
    Aug
  • £455
    Sep

Flight FAQs

  • Which airlines offer the cheapest flights from Medellin to Sao Paulo?

    Based on Trip.com data, LATAM Airlines offers Cheapest nonstop one-way flights from £214 (for example, MDE–GRU on Sat, Nov 28). For a Cheapest nonstop return flight, JetSMART Airlines offers fares from £363, departing on Sun, Oct 25 and returning on Thu, Oct 29.
  • At the moment, several airlines serve connecting flights from Medellin to Sao Paulo, including: avianca Gol Linhas Aereas Inteligentes Copa Airlines LATAM Airlines Selected airlines are based on historical data collected from flight bookings made by users on Trip.com within the last 90 days.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Medellin to Sao Paulo is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • Here are some tips for finding the best flight deals from Medellin to Sao Paulo on Trip.com:
    · Be flexible with your travel dates. The cheapest flight is currently on Sat, Nov 28, with one-way fares from just £214.
    · Compare airlines. LATAM Airlines currently offers the lowest fares on this route.
    · Set up a price alert to track fare changes without searching every day.
    · Check Trip.com regularly for flight deals and available promo codes.
    · Avoid peak season or book early. January is generally the busiest month for travel to Sao Paulo.
    · Get exclusive promo codes on the Trip.com app.
  • The cheapest month to book a flight from Medellin to Sao Paulo is usually September, when demand is lower.
  • After crunching the numbers on our October flight calendar, it's currently cheapest to fly from Medellin to Sao Paulo on October 12, 2026 with LATAM Airlines, with prices starting at £214.
  • Flights to Sao Paulo can arrive at: São Paulo–Congonhas Airport (CGH), São Paulo/Guarulhos–Governor André Franco Montoro International Airport (GRU) and Viracopos International Airport (VCP). The most common route connects Jose Maria Cordova International Airport and São Paulo/Guarulhos–Governor André Franco Montoro International Airport (MDE–GRU).
  • The time difference between Sao Paulo and Medellin is 2h.
  • Tickets can only be changed or cancelled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.
  • Based on Trip.com data for flights departing in the next 30 days, the average one-way fare from Medellin to Sao Paulo is £329. Fares vary by travel date, airline and availability.
  • Enter Medellin and Sao Paulo, choose your travel dates and passengers, then compare flights by price, duration and baggage. Select a fare, review the change and cancellation rules, enter traveller details and complete payment to receive your confirmation.
  • Gol Linhas Aereas Inteligentesare the most popular budget airlines flying from Medellin to Sao Paulo. Check baggage, seat and payment fees before comparing the final price.

More Flight Itineraries

Note: Prices shown on this page are the estimated lowest prices and include all taxes and fees found in the last 24 hours.

Book with no extra fees

Prices displayed on this page are all-inclusive (including taxes, fuel surcharges, civil aviation development fund, etc.), with all fees confirmed before payment. Fees for luggage, meals, Wi-Fi, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page have been updated within the last 24 hours—sometimes even in real time. The more popular the route, the more accurate the data.

Change & Cancellation Policy

Trip.com shows the cancellation and change policies for each flight ticket during the booking process, including any fees and applicable conditions. Please check the following scenarios:
Voluntary cancellation/change:
To request a change or cancellation, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and flight segment, and submit your request. Please note that additional charges may apply according to the airline's ticket policy.
Cancellation/change due to a flight schedule change:
If the flight schedule has changed and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please visit the customer support pages.