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Flights from Santiago to Sao Paulo

Explore the cheapest one-way and round-trip flights from Santiago to Sao Paulo over the next 90 days, with one-way fares from £79 and round-trip from £137. Based on Trip.com's latest 7-day flight data.

      • Cheapest nonstop
        SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Thu, Oct 1 | Sky Airline
        GRU 13:00
        4h 16m
        Direct
        SCL 17:16
        Sao Paulo - Santiago | Sun, Oct 4 | Sky Airline
        £137 £278
        51% off
        51% off
        £278 £137
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Mon, Oct 26 | Sky Airline
        GRU 13:00
        4h 16m
        Direct
        SCL 17:16
        Sao Paulo - Santiago | Fri, Oct 30 | Sky Airline
        £141 £278
        49% off
        49% off
        £278 £141
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Fri, Oct 2 | Sky Airline
        GRU 13:00
        4h 16m
        Direct
        SCL 17:16
        Sao Paulo - Santiago | Sun, Oct 4 | Sky Airline
        £143 £278
        49% off
        49% off
        £278 £143
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Mon, Oct 19 | Sky Airline
        GRU 13:00
        4h 16m
        Direct
        SCL 17:16
        Sao Paulo - Santiago | Mon, Oct 26 | Sky Airline
        £150
        46% off
        £278 £150
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Thu, Oct 15 | Sky Airline
        GRU 13:00
        4h 16m
        Direct
        SCL 17:16
        Sao Paulo - Santiago | Thu, Oct 22 | Sky Airline
        £150
        46% off
        £278 £150
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Sun, Oct 25 | Sky Airline
        GRU 13:00
        4h 15m
        Direct
        SCL 17:15
        Sao Paulo - Santiago | Mon, Nov 2 | Sky Airline
        £152
        45% off
        £278 £152
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Thu, Oct 29 | Sky Airline
        GRU 13:00
        4h 16m
        Direct
        SCL 17:16
        Sao Paulo - Santiago | Fri, Oct 30 | Sky Airline
        £157
        44% off
        £278 £157
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Fri, Oct 9 | Sky Airline
        GRU 13:00
        4h 16m
        Direct
        SCL 17:16
        Sao Paulo - Santiago | Wed, Oct 14 | Sky Airline
        £162
        42% off
        £278 £162
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Sat, Oct 10 | Sky Airline
        GRU 13:00
        4h 16m
        Direct
        SCL 17:16
        Sao Paulo - Santiago | Sat, Oct 17 | Sky Airline
        £164
        41% off
        £278 £164
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Fri, Oct 16 | Sky Airline
        GRU 13:00
        4h 16m
        Direct
        SCL 17:16
        Sao Paulo - Santiago | Fri, Oct 23 | Sky Airline
        £211
        24% off
        £278 £211
      • SCL 13:00
        17h 25m
        1 stop
        SAO 14:00
        Santiago - Sao Paulo | Wed, Sep 16 | Normal Airline
        SAO 15:00
        6h
        Direct
        SCL 16:00
        Sao Paulo - Santiago | Fri, Sep 18 | Normal Airline
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      • Cheapest nonstop
        SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Fri, Oct 23 | Sky Airline
        £79 £120
        34% off
        34% off
        £120 £79
      • SCL 07:45
        3h 50m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Mon, Nov 9 | Sky Airline
        £83 £120
        31% off
        31% off
        £120 £83
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Thu, Oct 22 | Sky Airline
        £88 £120
        27% off
        27% off
        £120 £88
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Sun, Oct 25 | Sky Airline
        £89
        26% off
        £120 £89
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Sun, Oct 11 | Sky Airline
        £91
        24% off
        £120 £91
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Mon, Oct 26 | Sky Airline
        £91
        24% off
        £120 £91
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Sat, Oct 24 | Sky Airline
        £91
        24% off
        £120 £91
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Thu, Oct 1 | Sky Airline
        £91
        24% off
        £120 £91
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Fri, Oct 9 | Sky Airline
        £91
        24% off
        £120 £91
      • SCL 07:43
        3h 52m
        Direct
        GRU 11:35
        Santiago - Sao Paulo | Tue, Oct 6 | Sky Airline
        £91
        24% off
        £120 £91
      • SCL 13:00
        17h 25m
        1 stop
        SAO 14:00
        Santiago - Sao Paulo | Wed, Sep 16 | Normal Airline
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        Find more flights

Flight.News
INMET has issued weather warnings for Sao Paulo starting 14/09/2026 at 00:00. Expect rainfall between 20 and 60 mm/h (up to 100 mm/day), intense winds of 40–100 km/h, hail, and lightning. Potential hazards include power cuts, falling tree branches, flooding, and crop damage.
Flights from Santiago to Sao Paulo operate an average of 28 times per day over the past 7 days, with a 14.5% on-time departure rate and a 78.1% on-time arrival rate.

Which airlines are the most popular for Santiago to Sao Paulo flights?

The most popular airlines flying from Santiago to Sao Paulo are JetSMART Airlines, Sky Airline, and LATAM Airlines, among 4 carriers on this route. Sky Airline offers the lowest fares. Based on Trip.com's flight booking data from the previous 12 months.
JetSMART Airlines logo JetSMART Airlines
Sky Airline logo Sky Airline
LATAM Airlines logo LATAM Airlines
Turkish Airlines logo Turkish Airlines
Airlines are determined based on actual purchased flight tickets from Santiago to Sao Paulo according to previous 12 months data from Trip.com.

Trip.com Price Insights on Santiago to Sao Paulo Flights

What is the cheapest month to book a one-way flight from Santiago to Sao Paulo?

Average price of one-way tickets from Santiago to Sao Paulo booked on Trip.com over the past 12 months.

For a one-way flight from Santiago to Sao Paulo, fares are lowest in October (£116) and highest in April (£224).

£224
£170
£116
£62
    Cheapest
  • £124
    Sep
  • £116
    Oct
  • £130
    Nov
  • £132
    Dec
  • £214
    Jan
  • £181
    Feb
  • £160
    Mar
  • £224
    Apr
  • £195
    May
  • £145
    Jun
  • £143
    Jul
  • £168
    Aug

What is the cheapest month to book a return flight from Santiago to Sao Paulo?

Average price of return tickets from Santiago to Sao Paulo booked on Trip.com over the past 12 months.

For a return flight from Santiago to Sao Paulo, fares are lowest in September (£197) and highest in January (£409).

£409
£303
£197
£91
  • £197
    Sep
  • £235
    Oct
  • £256
    Nov
  • £280
    Dec
  • £409
    Jan
  • £272
    Feb
  • £245
    Mar
  • £310
    Apr
  • £279
    May
  • £237
    Jun
  • £295
    Jul
  • £234
    Aug

Flight FAQs

  • Which airlines offer the cheapest flights from Santiago to Sao Paulo?

    Based on Trip.com data, Sky Airline offers Cheapest nonstop one-way flights from £79 (for example, SCL–GRU on Fri, Oct 23). For a Cheapest nonstop return flight, Sky Airline offers fares from £137, departing on Thu, Oct 1 and returning on Sun, Oct 4.
  • At the moment, you can catch a direct flight from Santiago to Sao Paulo with the following airlines, including: JetSMART Turkish Airlines LATAM Airlines Sky Airline Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.
  • A flight from Santiago (SCL) to Sao Paulo (SAO) takes an average of 3 hours 59 minutes.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Santiago to Sao Paulo is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • On average, 69 direct flights operate each week between Santiago and Sao Paulo. See below the schedules of the main airlines serving this route:
    LATAM Airlines: S/M/T/W/T/F/S – LA754 (departure at 09:41)
  • Here are some tips for finding the best flight deals from Santiago to Sao Paulo on Trip.com:
    · Be flexible with your travel dates. The cheapest flight is currently on Fri, Oct 23, with one-way fares from just £79.
    · Compare airlines. Sky Airline currently offers the lowest fares on this route.
    · Set up a price alert to track fare changes without searching every day.
    · Check Trip.com regularly for flight deals and available promo codes.
    · Avoid peak season or book early. January is generally the busiest month for travel to Sao Paulo.
    · Get exclusive promo codes on the Trip.com app.
  • The cheapest month to book a flight from Santiago to Sao Paulo is usually December, when demand is lower.
  • After crunching the numbers on our September flight calendar, it's currently cheapest to fly from Santiago to Sao Paulo on September 27, 2026 with LATAM Airlines, with prices starting at £173.
  • Flights to Sao Paulo can arrive at: São Paulo–Congonhas Airport (CGH), São Paulo/Guarulhos–Governor André Franco Montoro International Airport (GRU) and Viracopos International Airport (VCP). The most common route connects Arturo Merino Benitez International Airport and São Paulo/Guarulhos–Governor André Franco Montoro International Airport (SCL–GRU).
  • The time difference between Sao Paulo and Santiago is 1h.
  • Tickets can only be changed or cancelled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.
  • Based on Trip.com data for flights departing in the next 30 days, the average one-way fare from Santiago to Sao Paulo is £185. Fares vary by travel date, airline and availability.
  • Based on Trip.com data for flights departing in the next 30 days, the average return fare from Santiago to Sao Paulo is £299. Fares vary by travel date, airline and availability.
  • Enter Santiago and Sao Paulo, choose your travel dates and passengers, then compare flights by price, duration and baggage. Select a fare, review the change and cancellation rules, enter traveller details and complete payment to receive your confirmation.
  • Sky Airline and JetSMARTare the most popular budget airlines flying from Santiago to Sao Paulo. Check baggage, seat and payment fees before comparing the final price.

More Flight Itineraries

Note: Prices shown on this page are the estimated lowest prices and include all taxes and fees found in the last 24 hours.

Book with no extra fees

Prices displayed on this page are all-inclusive (including taxes, fuel surcharges, civil aviation development fund, etc.), with all fees confirmed before payment. Fees for luggage, meals, Wi-Fi, or other additional services are also included as shown in the flight cards.

Real-time pricing updates

Prices, availability, and travel information on this page have been updated within the last 24 hours—sometimes even in real time. The more popular the route, the more accurate the data.

Change & Cancellation Policy

Trip.com shows the cancellation and change policies for each flight ticket during the booking process, including any fees and applicable conditions. Please check the following scenarios:
Voluntary cancellation/change:
To request a change or cancellation, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and flight segment, and submit your request. Please note that additional charges may apply according to the airline's ticket policy.
Cancellation/change due to a flight schedule change:
If the flight schedule has changed and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please visit the customer support pages.