Venice is divided into six districts: Canaregio, Sao Paulo, Dolso Duro, Saint Cross, Saint Mark and Castle. Dolso Duro is on the south side of Venice, including Judeka and Sacafisola. This area is the highest elevation on Venice Island. Dolso Duro means Italian "Ridge" which means relatively high and stable land. Famous buildings in this area include the Academy Bridge, Peggy Guggenham Art Museum, Notre Dame Rose Hall and so on.
Dorsoduro is the first sestieri I stayed in on my first visit to Venice. It was explained to me as the "young people's" district and the one where all the night life is. Venice, in my experience, doesn't have a crazy night life scene, but if you are going to find one, much of it will be here.
This lovely neighborhood is home to the Guggenheim and has lovely views of San Marco from across the water.
Riverside buildings always have a sense of unrepaired fragmentation, located in Dolso Duro, south of Venice, with relatively sparse waterways.
Located in the southern part of the Grand Canal, in Dolso Duro on the southern side of Venice, the waterway is relatively sparse.