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Flights from Santa Ana to Knoxville
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Flights from Santa Ana to Knoxville Starting at €123

Whether you’re going for a one-way or round-trip to Knoxville, we’ve got you covered! Check out these different flight options from Santa Ana below.

  • One way
  • Round-trip
      • SNA12:30
        24h 13m
        1 stop
        TYS15:43
        Sat, Mar 8|Santa Ana - Knoxville|Frontier Airlines
        €123€362
        66% OFF
        66% OFF
        €362€123

        Choose Frontier Airlines flights from Santa Ana to Knoxville. The one-way connecting flight with Frontier Airlines departs from John Wayne Airport on Sat, Mar 8, arriving at Mcghee Tyson Airport. One-way Prices start from €123 including taxes and charges.

      • SNA06:45
        6h 49m
        1 stop
        TYS16:34
        Sat, Feb 15|Santa Ana - Knoxville|Delta Air Lines
        €128€362
        65% OFF
        65% OFF
        €362€128

        Choose Delta Air Lines flights from Santa Ana to Knoxville. The one-way connecting flight with Delta Air Lines departs from John Wayne Airport on Sat, Feb 15, arriving at Mcghee Tyson Airport. One-way Prices start from €128 including taxes and charges.

      • SNA06:45
        8h 22m
        1 stop
        TYS18:07
        Sat, Feb 15|Santa Ana - Knoxville|United Airlines
        €152€362
        57% OFF
        57% OFF
        €362€152

        Choose United Airlines flights from Santa Ana to Knoxville. The one-way connecting flight with United Airlines departs from John Wayne Airport on Sat, Feb 15, arriving at Mcghee Tyson Airport. One-way Prices start from €152 including taxes and charges.

      • SNA07:45
        6h 50m
        1 stop
        TYS17:35
        Sat, Feb 15|Santa Ana - Knoxville|American Airlines
        €152
        €152

        Choose American Airlines flights from Santa Ana to Knoxville. The one-way connecting flight with American Airlines departs from John Wayne Airport on Sat, Feb 15, arriving at Mcghee Tyson Airport. One-way Prices start from €152 including taxes and charges.

      • SNA12:00
        8h 47m
        1 stop
        TYS23:47
        Fri, Feb 14|Santa Ana - Knoxville|Delta Air Lines
        €239
        €239

        Choose Delta Air Lines flights from Santa Ana to Knoxville. The one-way connecting flight with Delta Air Lines departs from John Wayne Airport on Fri, Feb 14, arriving at Mcghee Tyson Airport. One-way Prices start from €239 including taxes and charges.

      • SNA21:20
        8h 56m
        1 stop
        TYS09:16
        Mon, Feb 17|Santa Ana - Knoxville|Delta Air Lines
        €242
        €242

        Choose Delta Air Lines flights from Santa Ana to Knoxville. The one-way connecting flight with Delta Air Lines departs from John Wayne Airport on Mon, Feb 17, arriving at Mcghee Tyson Airport. One-way Prices start from €242 including taxes and charges.

      • SNA21:30
        8h 52m
        1 stop
        TYS09:22
        Mon, Mar 24|Santa Ana - Knoxville|Delta Air Lines
        €263
        €263

        Choose Delta Air Lines flights from Santa Ana to Knoxville. The one-way connecting flight with Delta Air Lines departs from John Wayne Airport on Mon, Mar 24, arriving at Mcghee Tyson Airport. One-way Prices start from €263 including taxes and charges.

      • SNA21:20
        8h 56m
        1 stop
        TYS09:16
        Thu, Mar 6|Santa Ana - Knoxville|Delta Air Lines
        €264
        €264

        Choose Delta Air Lines flights from Santa Ana to Knoxville. The one-way connecting flight with Delta Air Lines departs from John Wayne Airport on Thu, Mar 6, arriving at Mcghee Tyson Airport. One-way Prices start from €264 including taxes and charges.

      • SNA07:45
        12h 15m
        1 stop
        TYS23:00
        Sat, Feb 15|Santa Ana - Knoxville|Alaska Airlines
        €269
        €269

        Choose Alaska Airlines flights from Santa Ana to Knoxville. The one-way connecting flight with Alaska Airlines departs from John Wayne Airport on Sat, Feb 15, arriving at Mcghee Tyson Airport. One-way Prices start from €269 including taxes and charges.

      • SNA10:46
        9h 14m
        1 stop
        TYS23:00
        Fri, Feb 14|Santa Ana - Knoxville|United Airlines
        €283
        €283

        Choose United Airlines flights from Santa Ana to Knoxville. The one-way connecting flight with United Airlines departs from John Wayne Airport on Fri, Feb 14, arriving at Mcghee Tyson Airport. One-way Prices start from €283 including taxes and charges.

      • SNA01:00 pm
        3h 5m
        Nonstop
        TYS02:00 pm
        Tue, Feb 18|Santa Ana - Knoxville|Frontier Airlines
        Find More Flights
        Find More Flights

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Santa Ana to Knoxville flight time & flight schedules

Flight info.
Departure
Arrival
Weekly Schedule

  1. UA1515

    United Airlines

    06:45

    SNA

    3.2h

    11:58

    IAH

    S--WTFS
    Search

  2. UA4890

    United Airlines

    14:35

    IAH

    2.4h

    17:56

    TYS

    SMTWTFS

  3. DL721

    Delta Air Lines

    06:45

    SNA

    4.4h

    14:08

    ATL

    SMTWTFS
    Search

  4. DL4886

    Delta Air Lines

    17:38

    ATL

    1.0h

    18:37

    TYS

    SMTWTFS

  5. DL721

    Delta Air Lines

    06:45

    SNA

    4.4h

    14:08

    ATL

    SMTWTFS
    Search

  6. DL5472

    Delta Air Lines

    14:12

    ATL

    0.9h

    15:08

    TYS

    SMTWTFS

  7. AA1539

    American Airlines

    07:45

    SNA

    4.8h

    15:32

    CLT

    SMTWTFS
    Search

  8. AA5966

    American Airlines

    16:24

    CLT

    1.2h

    17:35

    TYS

    SM-WTFS

  9. UA1284

    United Airlines

    08:15

    SNA

    3.1h

    13:24

    IAH

    S--WTFS
    Search

  10. UA4900

    United Airlines

    16:20

    IAH

    2.4h

    19:41

    TYS

    SMTWTFS

  11. UA798

    United Airlines

    10:55

    SNA

    2.4h

    14:17

    DEN

    -MT----
    Search

  12. UA4798

    United Airlines

    17:25

    DEN

    3.1h

    22:29

    TYS

    SMTWTFS

  13. DL426

    Delta Air Lines

    12:00

    SNA

    4.1h

    19:05

    ATL

    S-TWT-S
    Search

  14. DL3072

    Delta Air Lines

    22:50

    ATL

    0.9h

    23:46

    TYS

    SMTWTFS

  15. DL1327

    Delta Air Lines

    13:10

    SNA

    3.7h

    18:51

    MSP

    S--WT--
    Search

  16. DL5527

    Delta Air Lines

    19:45

    MSP

    2.2h

    22:55

    TYS

    SMTWTFS

  17. AA2462

    American Airlines

    13:29

    SNA

    4.2h

    19:38

    ORD

    SMTWTFS
    Search

  18. AA4494

    American Airlines

    20:15

    ORD

    1.7h

    22:59

    TYS

    ----T--

  19. AA2465

    American Airlines

    15:09

    SNA

    3.0h

    20:09

    DFW

    SMTWTFS
    Search

  20. AA1081

    American Airlines

    20:51

    DFW

    2.1h

    23:59

    TYS

    SMTWTFS
Find more flights and airlines

Find the best time to fly from Santa Ana to Knoxville

Price trend charts are a great way of tracking how much your flights cost in the lead up to departure and can help you choose when to book your tickets. See how prices to Knoxville from Santa Ana have changed and are set to move below.

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

FAQ

  • When are flight tickets from Santa Ana (SNA) to Knoxville (TYS) the cheapest?

    Airlines adjust prices for flights from Santa Ana to Knoxville based on the date and time of your booking. By analyzing data from all airlines, on Trip.com, you can find the cheapest flight prices on Tuesdays, Wednesdays, and Saturdays.

  • How much are flights from Santa Ana (SNA) to Knoxville (TYS) cost?

    According to Trip.com's data, the lowest price is around €508.

  • How many airports in Knoxville (TYS)?

    There are 1 airport(s) in Knoxville (TYS): Mcghee Tyson Airport.

How to find a cheap flight from Santa Ana to Knoxville

Understanding the common pitfalls when booking your flight tickets can help you save massively when it comes time to fly. We’ve listed our six essential steps to keep in mind when you’re booking flight tickets to help you find the best price.
1
Book Early
Once prices are gone, they're gone. Lock in deals while you can!
2
Compare Flight Prices
Compare prices on travel agency and airline websites.
3
Look Out for Deals
Check airline and travel agency websites for latest flight deals
4
Check One-way Fares
Buying two cheap one-way flights can sometimes be a better deal than a round-trip.
5
Try Different Dates
Flying during the week, early in the morning, or late at night can help save money.
6
Use the Trip.com App
Save up to £10 per person when booking your flights on Trip.com

Flight Information from Santa Ana to Knoxville

Cheapest direct flight price€123
Off-season travel monthFebruary
Peak season for travelMay
Flight distance3,088.82km
Popular airlineAmerican Airlines

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