App
Customer Support
NZD
Find Bookings
Trip.com
>
Cheap Flights
>
Belgium
>
Brussels-Capital Region
>
Brussels
>
Flights from Des Moines to Brussels
Worldwide Coverage
Worldwide Coverage
Flights to over 5,000 cities
One-stop Service Guarantee
One-stop Service Guarantee
Price guaranteed upon confirmed payment, booking guaranteed once tickets issued
Secure Payment
Secure Payment
Convenient & reliable booking and payment system

Flights from Des Moines to Brussels Starting at NZD 851

For as little as NZD 851, you can take your next adventure to Brussels without breaking the bank. Choose between one-way and return tickets from Des Moines below.

  • One way
  • Round-trip
      • DSM08:10
        17h 45m
        1 stop
        BRU07:55
        Sun, Mar 9|Des Moines - Brussels|United Airlines
        NZD 851NZD 1,513
        44% OFF
        44% OFF
        NZD 1,513NZD 851

        Choose United Airlines flights from Des Moines to Brussels. The one-way connecting flight with United Airlines departs from Des Moines International Airport on Sun, Mar 9, arriving at Brussels National Airport. One-way Prices start from NZD 851 including taxes and charges.

      • DSM08:00
        17h 55m
        1 stop
        BRU08:55
        Mon, Mar 3|Des Moines - Brussels|United Airlines
        NZD 852NZD 1,513
        44% OFF
        44% OFF
        NZD 1,513NZD 852

        Choose United Airlines flights from Des Moines to Brussels. The one-way connecting flight with United Airlines departs from Des Moines International Airport on Mon, Mar 3, arriving at Brussels National Airport. One-way Prices start from NZD 852 including taxes and charges.

      • DSM08:00
        17h 55m
        1 stop
        BRU08:55
        Wed, Feb 26|Des Moines - Brussels|United Airlines
        NZD 854NZD 1,513
        44% OFF
        44% OFF
        NZD 1,513NZD 854

        Choose United Airlines flights from Des Moines to Brussels. The one-way connecting flight with United Airlines departs from Des Moines International Airport on Wed, Feb 26, arriving at Brussels National Airport. One-way Prices start from NZD 854 including taxes and charges.

      • DSM15:28
        10h 27m
        1 stop
        BRU07:55
        Wed, Mar 26|Des Moines - Brussels|United Airlines
        NZD 878
        NZD 878

        Choose United Airlines flights from Des Moines to Brussels. The one-way connecting flight with United Airlines departs from Des Moines International Airport on Wed, Mar 26, arriving at Brussels National Airport. One-way Prices start from NZD 878 including taxes and charges.

      • DSM08:50
        18h 10m
        1 stop
        BRU09:00
        Sun, Mar 9|Des Moines - Brussels|Delta Air Lines
        NZD 887
        NZD 887

        Choose Delta Air Lines flights from Des Moines to Brussels. The one-way connecting flight with Delta Air Lines departs from Des Moines International Airport on Sun, Mar 9, arriving at Brussels National Airport. One-way Prices start from NZD 887 including taxes and charges.

      • DSM17:17
        33h 43m
        1 stop
        BRU09:00
        Tue, Mar 25|Des Moines - Brussels|Delta Air Lines
        NZD 888
        NZD 888

        Choose Delta Air Lines flights from Des Moines to Brussels. The one-way connecting flight with Delta Air Lines departs from Des Moines International Airport on Tue, Mar 25, arriving at Brussels National Airport. One-way Prices start from NZD 888 including taxes and charges.

      • DSM07:20
        19h 40m
        1 stop
        BRU09:00
        Wed, Mar 26|Des Moines - Brussels|Delta Air Lines
        NZD 911
        NZD 911

        Choose Delta Air Lines flights from Des Moines to Brussels. The one-way connecting flight with Delta Air Lines departs from Des Moines International Airport on Wed, Mar 26, arriving at Brussels National Airport. One-way Prices start from NZD 911 including taxes and charges.

      • DSM08:10
        17h 45m
        1 stop
        BRU07:55
        Tue, Mar 25|Des Moines - Brussels|United Airlines
        NZD 911
        NZD 911

        Choose United Airlines flights from Des Moines to Brussels. The one-way connecting flight with United Airlines departs from Des Moines International Airport on Tue, Mar 25, arriving at Brussels National Airport. One-way Prices start from NZD 911 including taxes and charges.

      • DSM08:00
        17h 55m
        1 stop
        BRU08:55
        Fri, Feb 28|Des Moines - Brussels|United Airlines
        NZD 941
        NZD 941

        Choose United Airlines flights from Des Moines to Brussels. The one-way connecting flight with United Airlines departs from Des Moines International Airport on Fri, Feb 28, arriving at Brussels National Airport. One-way Prices start from NZD 941 including taxes and charges.

      • DSM15:25
        10h 30m
        1 stop
        BRU07:55
        Fri, Mar 28|Des Moines - Brussels|United Airlines
        NZD 972
        NZD 972

        Choose United Airlines flights from Des Moines to Brussels. The one-way connecting flight with United Airlines departs from Des Moines International Airport on Fri, Mar 28, arriving at Brussels National Airport. One-way Prices start from NZD 972 including taxes and charges.

      • DSM01:00 pm
        3h 5m
        Nonstop
        BRU02:00 pm
        Tue, Mar 4|Des Moines - Brussels|United Airlines
        Find More Flights
        Find More Flights

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Des Moines to Brussels flight time & flight schedules

Flight info.
Departure
Arrival
Weekly Schedule

  1. UA1363

    United Airlines

    08:00

    DSM

    1.5h

    09:28

    ORD

    SMTWTFS
    Search

  2. UA1869

    United Airlines

    11:15

    ORD

    1.9h

    14:11

    IAD

    ---W---

  3. UA950

    United Airlines

    17:45

    IAD

    7.5h

    07:15

    BRU

    SMTWTFS

  4. UA1363

    United Airlines

    08:00

    DSM

    1.5h

    09:28

    ORD

    SMTWTFS
    Search

  5. UA1097

    United Airlines

    11:15

    ORD

    2.0h

    14:13

    DCA

    SMTWTFS

  6. UA950

    United Airlines

    17:45

    IAD

    7.5h

    07:15

    BRU

    SMTWTFS

  7. LH8763

    Lufthansa

    11:20

    DSM

    1.6h

    12:55

    ORD

    SMT-TFS
    Search

  8. LH7949

    Lufthansa

    17:55

    ORD

    8.1h

    09:00

    BRU

    SMTWTFS

  9. UA1373

    United Airlines

    11:29

    DSM

    1.5h

    12:57

    ORD

    SMTWT--
    Search

  10. UA972

    United Airlines

    17:55

    ORD

    8.1h

    09:00

    BRU

    SMTWTFS

  11. SK3231

    Scandinavian Airlines

    14:14

    DSM

    2.2h

    17:25

    ATL

    S-T-TF-
    Search

  12. SK930

    Scandinavian Airlines

    19:55

    ATL

    8.9h

    10:50

    CPH

    S-T-TF-

  13. SK1593

    Scandinavian Airlines

    12:45

    CPH

    1.5h

    14:15

    BRU

    SMTWT-S

  14. UA4393

    United Airlines

    15:15

    DSM

    1.5h

    16:45

    ORD

    SMTWTFS
    Search

  15. UA972

    United Airlines

    17:55

    ORD

    8.1h

    09:00

    BRU

    SMTWTFS

  16. KL7343

    KLM

    16:20

    DSM

    1.2h

    17:32

    MSP

    SMTWTFS
    Search

  17. KL6064

    KLM

    15:50

    MSP

    8.1h

    06:55

    AMS

    SMTWTFS

  18. KL1703

    KLM

    09:25

    AMS

    0.8h

    10:10

    BRU

    SMTWTFS

  19. KL5762

    KLM

    18:30

    DSM

    2.2h

    21:40

    ATL

    SMTWTFS
    Search

  20. KL622

    KLM

    22:40

    ATL

    8.5h

    13:10

    AMS

    SMTWTFS

  21. KL1705

    KLM

    13:50

    AMS

    0.8h

    14:35

    BRU

    SMTWTFS

  22. LH7635

    Lufthansa

    18:45

    DSM

    1.6h

    20:20

    ORD

    SMTWTFS
    Search

  23. LH435

    Lufthansa

    21:40

    ORD

    8.5h

    13:10

    MUC

    SMTWTFS

  24. LH5626

    Lufthansa

    14:55

    MUC

    1.3h

    16:15

    BRU

    SMTWTFS

  25. LH7635

    Lufthansa

    18:45

    DSM

    1.6h

    20:20

    ORD

    SMTWTFS
    Search

  26. LH435

    Lufthansa

    21:40

    ORD

    8.5h

    13:10

    MUC

    SMTWTFS

  27. LH2288

    Lufthansa

    14:40

    MUC

    1.4h

    16:05

    BRU

    SMTWTFS
Find more flights and airlines

Find the best time to fly from Des Moines to Brussels

Explore the best time to buy affordable tickets to Brussels with our price trend chart, which predicts how flight prices will change in the coming weeks from previous data.

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

FAQ

  • When are flight tickets from Des Moines (DSM) to Brussels (BRU) the cheapest?

    Airlines adjust prices for flights from Des Moines to Brussels based on the date and time of your booking. By analyzing data from all airlines, on Trip.com, you can find the cheapest flight prices on Tuesdays, Wednesdays, and Saturdays.

  • How much are flights from Des Moines (DSM) to Brussels (BRU) cost?

    According to Trip.com's data, the lowest price is around NZD 3,460.

  • What is the transportation method from the main airport to downtown in Brussels?

    • The distance from Brussels National Airport to downtown is about 10km, by taxi about 30 minutes.
    • The distance from Brussels South Charleroi Airport to downtown is about 43km, by taxi about 1 hour.

  • How many airports in Brussels (BRU)?

    There are 2 airport(s) in Brussels (BRU): Brussels National Airport and Brussels South Charleroi Airport.

How to find a cheap flight from Des Moines to Brussels

If you don’t know some of the key things to look out for when buying flight tickets, prices can often end up sky high or, worse, sold out! We’ve carefully compiled our six most important steps to help ensure you’re getting the best deals when planning your next journey.
1
Be flexible with your travel dates to get the cheapest flight from Des Moines to Brussels.
Simply tap "Date" on the flight search bar to browse through the calendar and check out airfare from Des Moines to Brussels over the next 6 months in 2025. If you're planning to fly within the next three months, it looks like the most affordable option is on Sun, Mar 9, with one-way flights priced at just NZD 851.
2
Compare cheap flight deals from Des Moines to Brussels across hundreds of airlines.
With our extensive search, you can compare prices from over 500 airlines to find the cheapest flight tickets from Des Moines to Brussels. The cheapest airline for this route is United Airlines.
3
Set up a Price Alert
By setting up a Price Alert for your journey from Des Moines to Brussels, you can easily keep an eye on ticket prices without having to check every day.
4
Don't miss out on cheap flight deals and promo codes from Des Moines to Brussels.
You can always find the latest offers through Trip.com Deals and Promo Codes for cheap flights. By signing up for a free membership, you'll get access to even more deals for your flights.
5
Book early or wait until the last minute.
It's usually best to book early. Flight tickets are often cheapest when they're first released, typically about a year before the departure date. So, have a look online as soon as the flights you're interested in become available. If you miss the cheapest time, you might still find some good deals as the departure date gets closer.
6
Search for flights on the go.
For the best travel flight booking experience, download the Trip.com app. You can search for cheap flights from Des Moines to Brussels and snag some exclusive deals just for you.

Flight Information from Des Moines to Brussels

Cheapest direct flight priceNZD 850
Off-season travel monthMarch
Peak season for travelDecember
Flight distance7,049.89km
Popular airlineAmerican Airlines

Contact Us

About

Other Services

Payment Methods
Our Partners
Copyright © 2025 Trip.com Travel Singapore Pte. Ltd. All rights reserved
Site Operator: Trip.com Travel Singapore Pte. Ltd.